Generation of null ranges via bootstrapping or covariate matching

Modular package for generation of sets of genomic features representing the null hypothesis. These can take the form of block bootstrap samples of ranges using the framework of Bickel et al 2010, or sets of control ranges that are matched across one or more covariates with a focal set. nullranges is designed to be inter-operable with other packages for analysis of genomic overlap enrichment, including the plyranges Bioconductor package.

An overview vignette can be found at the Get started tab above, while detailed vignettes on matching or bootstrapping can be found under Articles. The Reference tab lists function help pages.

You can browse the code or submit an Issue at the following link:

https://github.com/nullranges/nullranges

Installation

This package can be installed via Bioconductor:

BiocManager::install("nullranges")

Funding

This work was funded by the Chan Zuckerberg Initiative as part of the EOSS grants.

CZI